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These individual unimolecular multi-agonists activities seemed to harmonize the overall metabolic efficacy, which predominantly results from synergistic glucagon action to increase energy expenditure, GLP-1 action to reduce caloric intake and improve glucose control, and GIP action to potentiate the incretin effect and buffer against the diabetogenic effect of inherent glucagon activity

"Stability Profiles of Novel GLP-1 Receptor Agonists Under Variable Storage Conditions." Journal of Pharmaceutical Sciences , 113(4), 892-901

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However, some patients and providers find it helpful to check certain markers, especially if you have been off medication for an extended period or if you have specific health concerns