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Common and potential side effects include: Skin irritation : Redness, itching, rashes, or allergic reactions where the patch sits, especially with daily use Cardiovascular effects : Bitter orange extract can increase heart rate and blood pressure Digestive issues : Green tea extract may cause upset stomach or headaches Sleep problems : Caffeine content from green tea extract can disrupt sleep Liver concerns : Garcinia cambogia has been linked to liver problems in some cases Unknown risks : Lack of regulation means uncertain ingredient quality and quantities The bigger concern is that these products arent regulated in the same way as prescription medications

This small peptide is eliminated by the kidneys and has a plasma half-life of approximately 3 hours, requiring twice-daily subcutaneous injections

10.1371/journal.pone.0143731 37 HanssensM.KeirseM