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This extraordinary potency difference stems from Dihexas mechanism as an HGF mimetic binding to c-Met receptors, which triggers intracellular signaling cascades distinct from BDNFs TrkB receptor pathway

Both semaglutide and tirzepatide can lead to reductions in lean body mass through the same mechanism appetite suppression leading to reduced protein intake during caloric restriction

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At the time of discharge (3 months after admission), the patient was able to walk independently, and her weight and BMI had decreased to 104 kg and 50.8 kg/m 2 , respectively (Table 1)