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Similarly, in controlled clinical studies in patients with type 2 diabetes mellitus, the antihyperglycemic effect of metformin was comparable in males and females
Perforation risk increases dramatically after 48-72 hours of symptoms, jumping from less than 5% in the first 24 hours to over 50% if surgery is delayed beyond 3 days
This mechanistic distinction is scientifically significant because it frames BPC-157 as a cytoprotection-associated research peptide rather than as an acid-suppressive compound
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