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FIGURE 3 3.1 Nicotine AUD is often accompanied by nicotine dependence, as nicotine enhances the urge to consume alcohol and the two drugs enhance their corresponding behavioral responses [for a review, see GLP-1R gene ( 3.2 Opioids Although opioids such as morphine, remifentanil, heroin, and oxycodone largely share a common pharmacologic mechanism of action, namely, acting on opioid receptors, the ability of GLP-1R to regulate the behavioral responses to these opioids varies