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The combination is potent because it addresses psoriasis at both the regulatory level, why the immune system is attacking, and the effector level, the specific inflammatory signals doing the damage

The concurrent GLP-1 and GIP arms drive glucose-dependent insulin secretion that offsets glucagon-induced gluconeogenesis, producing net euglycaemia alongside elevated lipolysis (Jastreboff et al., NEJM, 2023) [1]

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The patients lost on average 43 pounds that was sustained at one year