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For years, the idea of activating glucagon receptors for weight loss seemed counterintuitive since glucagon raises blood sugar

Dent R, McPherson R, Harper ME

Underscoring the importance that direct cholesterol engagement has in the modulation of GLP-1R function, the changes in cholesterol binding and plasma membrane behaviours introduced by the V229A substitution led to significant effects on GLP-1R trafficking and signalling in beta cells: V229A caused a decrease in GLP-1R recruitment to CCPs and receptor internalisation, accompanied by an increase in G s (measured with mini-G s ) and -arrestin 2 engagement, as well as increased plasma membrane recycling following exendin-4 stimulation

It also increases inflammation around the follicle, potentially damaging the dermal papilla cells that drive new hair growth