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Throughout the world, methylene blue is currently approved for the treatment of numerous conditions, of which include acquired and hereditary methemoglobinemia, preventing ifosfamide-induced encephalopathy in cancer patients, preventing urinary tract infections, visualizing nerves and endocrine glands during surgical procedures, and sterilizing blood prior to transfusions 3

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Meanwhile, sacituzumab govitecan, an anti-TROP-2 ADC bearing SN-38, has gained approvals in metastatic breast and bladder cancer

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