These differences primarily involve energy metabolism (such as glucose, ketone bodies, glycine, creatinine, and citrate), as well as processes related to the bacterial microbiota (such as TMAO and formic acid) and detoxification (such as hippuric acid)
Least square mean changes from baseline in study outcomes and corresponding 95% confidence intervals (CI) were estimated using linear mixed-effects regression models, which included a fixed effect for study visit and random intercepts and slopes
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