nejm retatrutide 📊 Semaglutide 2.4mg: −13.7% weight loss (SURMOUNT-5 head-to-head), 📊 Tirzepatide 15mg: −20.2% weight loss (same trial, 2025), 📊 12mg: −28.7% weight loss (TRIUMPH-4, Phase 3, Dec Retatrutide 10mg & 20mg Research

That approval came after two pivotal Phase 3 trials involving more than 800 participants, where Tesamorelin demonstrated reductions in visceral adipose tissue (VAT) of 15 to 20% over 26 weeks

Because of this dual approach, tirzepatide has been shown to more effectively reduce blood sugar levels and ultimately lead to greater weight loss than single-agonist medications like semaglutide

The Issue of Weight Regain Research indicates that approximately 76% of individuals regain their lost weight after discontinuing GLP-1 injections, typically within two years

But VIBES works similarly to another device, Moran says