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Metabolic Effects Notable improvements in cardiometabolic markers were observed, including a reduction in LDL cholesterol by up to 23.0 mg/dL, a decrease in total cholesterol by 32.5 mg/dL, and a systolic blood pressure drop of up to 11.6 mmHg in the 1.2 mg group, indicating broader metabolic benefits beyond weight loss

Individualized Treatment Plans : Ultimately, the decision to use semaglutide in combination with other weight loss medications should be personalized, taking into account the patients health status, weight loss goals, and response to previous treatments

As of 2022, GLP-1RAs have been recommended as first-line treatments, along with SGLT-2 inhibitors, for patients with T2DM and cardiovascular disease in American Diabetes Associations Standards of Medical Care in Diabetes (248, 249)

Hong Kong J Nephrol