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A parallel-arm phase I trial of the humanised anti-IGF-1R antibody dalotuzumab in combination with the AKT inhibitor MK-2206, the mTOR inhibitor ridaforolimus, or the NOTCH inhibitor MK-0752, in patients with advanced solid tumours

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Expression of futile cycle markers was mixed, with decreased Alpl and increased mCBK , suggesting altered energy-wasting activity, though the direction of change remains unclear