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G., Skeen, J

At other temperatures, the results of Price (ref 29) and Tsonopoulos and Wilson (ref 40) are in quite good agreement up to 353 K but begin to diverge at higher temperatures (Table 2 and Figure 1)

Critically, UGT inhibition (not substrate activity) correlates with hepatotoxic potential.A drugs inhibition of UGT enzymes is a direct indicator of increased hepatotoxicity risk