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Safety data indicate mostly mild gastrointestinal events (nausea, diarrhea, vomiting), dose-dependent, and often improved with titration

Works well

Interaction between the non-catalytic cysteine at position 129 and the catalytic cysteine 227 shows the formation of a disulfide bond, which maintains its catalytic activity (91, 92)

The observation that patients with AD carrying two alleles of the APOE4 risk variant have approximately half the cerebrospinal fluid (CSF) melatonin levels compared to those with only one allele of this variant [75] could suggests that APOE4/4 carriers might particularly benefit from supplementing with exogenous melatonin