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R Hanif, L Qiao , SJ Shiff , B Riga - Curcumin, a natural plant phenolic food additive, inhibits cell proliferation and induces cell cycle changes in colon adenocarcinoma cell lines by a prostaglandin-independent pathway - J Lab Clin Med -1997 Dec

Even when lab values appear normal on medication, many patients still struggle with: Slowed metabolism Insulin resistance Increased fat storage Chronic inflammation Fatigue that limits physical activity These factors create a perfect storm where calorie restriction backfires, muscle mass declines, and weight loss stalls

You can even see the dose increase spikes on the side effects over time graph