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This is particularly true for potent compounds like Semaglutide or Tirzepatide , where rapid titration can lead to severe gastrointestinal distress

Covers: biochemistry of amylin, receptor biology (CTR + RAMP complex), physiological functions, clinical applications, the Pramlintide experience, perspectives for long-acting analogs

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Mechanisms (Preclinical Only) Rodent and in vitro studies report modulation of the nitric oxide system via SrcCaveolin1eNOS signaling and context dependent effects on vascular tone