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In the IRI model, PROTAC NP8 protects renal function by targeting histone deacetylase 6 (HDAC6), increasing the level of the renal protective protein klotho, and decreasing oxidative damage and apoptosis of renal tubular epithelial cells[84]

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The active site of the enzyme that binds glycine to the dipeptide -L-glutamyl-L-cysteine is highly specific (57)