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The N-terminal glycine amino group donates one nitrogen ligand to the copper, the imidazole nitrogen of the histidine side chain donates a second nitrogen ligand, and the deprotonated amide nitrogen of the Gly-His peptide bond donates a third nitrogen ligand
For patients experiencing intolerable constipation with tirzepatide, discussing alternative GLP-1 receptor agonists with their healthcare provider may be reasonable, though similar side effects may occur given the shared mechanism of action
The real question is which option fits your health history, your metabolism and your long-term goals
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