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In patients with MASH and F1-F3 stage fibrosis treated with survodutide for 48 weeks across doses ranging from 2.4 to 6.0 mg, regression of MASH without fibrosis progression did not show a dose-dependent trend, with the best response observed at 4.8 mg (62% vs

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GLP-1R agonists could repair mitochondrial damage in vitro , and promote mitochondrial biogenesis and antioxidant system peroxisome proliferator-activated receptor coactivator 1 (PGC-1) signaling pathway in vivo (188)

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