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Specifically, the use of GLP-1RAs results in a reduction in BP (reduction in systolic BP by 1 mmHg with lixisenatide and by 5.4 mmHg with semaglutide) through a natriuretic and vasodilatory effect, likely mediated by the atrial natriuretic peptide, released as a result of binding to specific receptors expressed in the atria [43]
In that study, the highest dose group reported an average weight loss of 28.7% at 68 weeks
Mounjaro (tirzepatide): Patients taking the 15 mg dose lowered their hemoglobin A1C (a way to measure blood sugar over time) by 2.4% in some studies
Preclinical studies have demonstrated that GLP-1 receptor agonists reduce neuroinflammation, reduce tau phosphorylation, reduce amyloid deposition, increase synaptic function, and improve memory formation
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