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One of the key strengths of this study is its integrative approach, combining oxidative stress, inflammatory, genetic, and epigenetic biomarkers with insights from multi-omics technologies and artificial intelligence applications

Our friends in the tirzepatide group ended up losing about 24.3% of their body weight from the start of the entire study, proving that tirzepatide is most effective when paired with diet and exercise

Acknowledgements The National Natural Science Foundation of China (82073144, J.W.), the Health Commission of Zhejiang Province (JBZX-202004, J.W.), the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China (LHDMD22H310005, J.W.)

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