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68 Conclusion Incretin analogues are very effective weight loss medications with cardiovascular, renal, respiratory and hepatic benefits, with emerging evidence suggesting potential neuroprotective effects

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The hypothesis of the link between PLC, inflammation and cancer has been also confirmed by Yang et al., who showed that knockdown of PLC by shRNA decreased not only PLC expression itself, but also the expression of inflammatory cytokines IL-6, TNF-, IL-2 and inflammation-associated genes TLR-4, MyD88 and phosphorylated STAT-3 [58]