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This latter finding has been bolstered by the discovery that thyrotropin-releasing hormone (TRH) gene expression, which has long been known to play a role in the leptin-satiety pathway, is also affected by MC-4R stimulation

In 2026, the FDA approved a new higher dose of Wegovy that may help some patients lose more weight

Maintaining a healthy lifestyle can help preserve your results over time

In fact, incorporating fiber into your diet is always important, but becomes especially essential while you're taking a weight management medication like semaglutide, adds Michelle Cardel, PhD, RD, head of global clinical research and nutrition at WeightWatchers