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Lixisenatide is a long-lasting GLP-1R agonist that crosses blood-brain barrier at very low doses (Hunter and Holscher, 2012)
Model building and refinement The structures of the LSN3160440GLP-1GLP-1RG s (PDB: 6VCB), GLP-1GLP1RG s (PDB: 6X18) and RGT1383GLP-1RG s (PDB: 6B3J) were used as an initial template for model building of compound 2, compound 2 plus GLP-1, and compound 2 plus LY3502970 bound complexes, respectively
Multi-Receptor Peptide Molecular Formula: CHNO CAS Number: 2381089-83-2 Molecular Weight: ~4730 g/mol Purity: 99.0% (validated by Certificate of Analysis) Appearance: White to off-white lyophilised powder Peptide Length: 39 amino acids Solubility: Soluble in appropriate laboratory solvents Quality Verification: Confirmed by RP-HPLC analytical testing Storage: Store under controlled laboratory conditions Full technical specifications and Certificate of Analysis documentation are available to support laboratory validation and procurement requirements
The GLP-1RAs@NPs were prepared by vortexing in an acetone solution, then centrifuged at 10,000 rpm for 10 min to obtain the GLP-1RAs@NPs precipitate
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