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Degraded semaglutide may not produce the same clean GLP-1 receptor activation, potentially causing irregular GI symptoms

In addition, GLP-1 also reduces ghrelin activity, a hormone with hunger-promoting effects [90, 92], and increases leptin sensitivity, a hormone with satiety-promoting affects [90, 93]

However, these studies individually are limited by small sample sizes, use of different comparison groups, and some lacked information on dose, which preclude a definitive assessment of the risk [see Data and Clinical Pharmacology (12.3)]

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