glp-1 and lupus nephropathy beyond immunosuppression: Searching for nephro cardioprotection At Lupus LA’s #LatestOnLupus Conference

doi: 10.1016/j.cmet.2006.02.002 178 KirkwoodT

Some cancer cells are very dependent on Mcl-1, which is the last line of defense keeping the cell from dying

This isnt a magic bullet GLP-1 drugs work, but theyre not without trade-offs: Gastrointestinal side effects : Nausea, vomiting, diarrhea affect users Muscle loss : Rapid weight loss can include lean muscle mass Rebound weight gain : Many patients regain weight after stopping treatment Long-term unknowns : We dont have 20-year safety data yet In India, where healthcare literacy varies widely, patient education and medical supervision will be critical

Shinozaki K, Yamaguchi-Shinozaki K