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A meta-analysis of 87 studies (9,109 participants) found that ASD children had significantly elevated blood levels of oxidative markers such as GSSG, malondialdehyde, and homocysteine, while significantly decreased levels of GSH, total glutathione, the GSH/GSSG ratio, and antioxidant substances such as cysteine, vitamin B9, and vitamin D

Several factors determine whether a peptide causes off-target hormonal activation, including receptor specificity, molecular structure, and signaling bias